Using genetic engineering, the researchers created mice with CINs that were unable to respond to Shh, and other mice whose CINs had elevated Shh signaling.
https://www.google.com/url?rct=j&sa=t&url=https://parkinsonsnewstoday.com/2021/09/28/imbalances-brain-dopamine-sonic-hedgehog-lid-l-dopa-induced-dyskinesia-parkinsons/&ct=ga&cd=CAIyGjg0YzkwMzEwZTQwYzQxNjA6Y29tOmVuOlVT&usg=AFQjCNFWonaPYJGzv8CdJuupkfy--7DS3Q
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